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Ac-CoA Synthase Inhibitor1
CAS No. 508186-14-9
Ac-CoA Synthase Inhibitor1( Ac-CoA Synthase Inhibitor I | MDK6149 | ACSS2 Inhibitor )
Catalog No. M18677 CAS No. 508186-14-9
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
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| 5MG | 59 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 168 | In Stock |
|
| 50MG | 294 | In Stock |
|
| 100MG | 439 | In Stock |
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| 500MG | 954 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAc-CoA Synthase Inhibitor1
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NoteResearch use only, not for human use.
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Brief DescriptionACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
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DescriptionMDK-6149, also known as ACSS2 Inhibitor or Ac-CoA Synthase Inhibitor I, is a Ac-CoA Synthase Inhibitor. MDK-6149 has CAS#508186-14-9. It was first reported in 2014. Cell. 159, 1591. For the convenience of scientific communication, we temporally name it as MDK-6149. The last 4 digit of its CAS# was used for name.
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In VitroAc-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 μM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM.
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In Vivo——
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SynonymsAc-CoA Synthase Inhibitor I | MDK6149 | ACSS2 Inhibitor
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorACSS2
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Research Area——
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Indication——
Chemical Information
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CAS Number508186-14-9
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Formula Weight410.51
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Molecular FormulaC20H18N4O2S2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 243.60 mM
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SMILESCOCCNC(=O)Nc2cc3nc(c1cccs1)c(nc3cc2)c4cccs4
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Chemical Name1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Comerford SA,etal.Acetate dependence of tumors.Cell. 2014 Dec 18;159(7):1591-602.
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